PTGS2 and ovarian carcinoma: Concanavalin A also induced apoptosis in ovarian cancer SKOV3 cells by modulating the expression of apoptosis-involved proteins cyclooxygenase 2 (COX-2), B-cell lymphoma 2 (Bcl-2), and serine-threonine protein kinase AKT and activating the Foxola-Bim signaling pathways [9].