Also, there was evidence that some therapeutic methods improved cognitive performance of transgenic mice without affecting Aβ burden: (1) Pyrrolidine dithiocarbamate improved spatial learning by regulating AKT-glycogen synthase kinase 3 signaling pathway in AβPP/PS1 mice without reducing Aβ load [6]; (2) no linear correlation was found between the worsening of memory function and the brain Aβ deposits, and some studies demonstrated that cognitive decline preceded plaque Aβ deposition [25]. The gene discussed is PSEN1; the disease is Mental deterioration.