Günther et al. [110] examined the impact of postsynaptic 5-HT1A-receptor overexpression in corticolimbic areas (which are thought to be part of the neuronal circuitry of depression [111]) of male and female mice (with female mice displaying higher receptor binding in the distinct brain areas) on the performance in the FST and suggested the involvement of postsynaptic 5-HT1A-receptors in the effects of SSRIs. This evidence concerns the gene HTR1A and major depressive disorder.