Fig 5 shows all risk haplotypes identified in cases and all non-risk haplotypes identified in controls from all three breeds. The ~167 kb haplotype harbours three genes, LHFPL5, SRPK1 and SLC26A8, which have not previously been implicated, and are thereby novel, with respect to the development of hypothyroidism. The gene discussed is SRPK1; the disease is hypothyroidism.