It includes acquired thrombophilia such as antiphospholipid antibody syndrome, activated protein C resistance, deficiencies in antithrombin III (ATIII), proteins C, S, and heritable causes such as factor V Leiden, Prothrombin (Factor II) G20210A, MTHFR C677T, PAI-1 4G/5G,  ACE I/D,  eNOS E298D, Apo E E2/E3/E4. This evidence concerns the gene MTHFR and antiphospholipid syndrome.