APP and Cognitive impairment: Spilman’s Statement S2 (“PDAPP mice accumulate soluble and deposited Aβ and develop AD-like synaptic deficits as well as cognitive impairment and hippocampal atrophy”) cites[111], shown as C2.1 (“...addition of the Swedish FAD mutation to the APP transgene in a second line of mice, further increased synaptic transmission deficits in young APP mice...”) in Figures 10 and11.