Liu et al. indicated that Th22 cells level and IL-22 expression in peripheral blood were significantly reduced in the newly diagnosed patients and complete remission patients compared to healthy controls indicating that Th22 might play a protective effect in AML.   21  However, as IL-22 is involved in the regulation of cell cycle control, cell growth and proliferation, it is possible that IL-22 might play a role during tumor genesis. The gene discussed is IL22; the disease is acute myeloid leukemia.