In ALL patients the lower levels of TNF-α and IL-6, and overexpression of TGF-β might suppress the differentiation of Th22 cells.        103  In a similar study in 2013, Cheng showed that the frequency of Th22 cells and the expression levels of IL-22, TNF-α and IL-22 mRNA in newly diagnosed patients and in patients with complete remission were significantly lower than healthy donors. This evidence concerns the gene TNF and acute lymphoblastic leukemia.