In AML newly-diagnosed group, IFN-γ concentration positively correlated with IL-21 and IL-22 level.   98  Conversely, Han et al. reported that plasma levels of the cytokines IL-1β, IL-6, IL-17, IL-22, IL-23 and TGF-β1 were significantly increased in blood and bone marrow in AML patients compared with healthy control. This evidence concerns the gene TGFB1 and acute myeloid leukemia.