IL22 and leukemia: Immunological disorders have shown to be related to the pathogenesis of some leukemias, as IL-22 is increased and correlates with CD38 expression in patients with B-chronic lymphocytic leukemia.        94  In addition, Th22 cells as the most important producers of IL-22 have been identified as major inducers of tissue inflammation and are thought to be implicated in the pathogenesis of some leukemic disorders.