Also in ALK+ALCL patients the serum levels of IL-22 and IL-17 are increased.        89  In transgenic mice model, it is shown that autocrine amplification of IL-22, and the inflammatory phenomenon observed in these mice correlates with the up-regulation of serum granulocyte colony-stimulating factor (G-CSF) and IL-17. Here, IL22 is linked to anaplastic large cell lymphoma.