High bone marrow iron storage, normal or elevated ferritin and decreased TIBC are features that distinguish it from IDA.2-4 In anemia of chronic disease, hepcidin concentration in response to the inflammatory cytokine interleukin 6 is increased.5 Hepcidine inhibits ferroportin by binding and internalizing it within the cell. The gene discussed is HAMP; the disease is anemia (phenotype).