The Chromosome 2 locus contains Ctnnbl1, a gene implicated in obesity (Liu et al. 2008; Tan et al. 2014) and two interesting candidates, bactericidal/permeability-increasing protein (Bpi) and lipopolysaccharide binding protein (Lpb). The gene discussed is CTNNBL1; the disease is obesity due to melanocortin 4 receptor deficiency.