CYP24A1 and neoplasm: Despite the general decrease in CYP24A1 mRNA in tumor specimens compared to the surgical margin, we found increased expression in higher (Stage I to III, UICC grading 1 to 3) developed tumors (rs=0.36; P<0.05, Spearman's test, P=0.001; Kruskal-Wallis ANOVA; Fig. 6D).