Recent findings implicate a specific subset of parasites that adhere to endothelial protein C receptor (EPCR) in severe childhood malaria.18 As EPCR plays a key role in regulating coagulation and endothelial cytoprotective and barrier properties,19 this raises the possibility there may be linkages between IE cytoadhesion and microvascular complications in CM.20 However, the precise molecular processes that account for the pathophysiological differences between CM1, CM2, and adult CM are poorly understood. This evidence concerns the gene PROCR and malaria.