All tumors could be classified into four subtypes according to ROR2 expression: (a) tumors with staining only in the tumor cells (cytoplasm) but not in stromal cells, (b) tumors with ROR2 expression in both compartments, (c) tumors with ROR2 confined to the tumor stroma, and (d) tumors without staining in tumor or stromal cells (Fig. 2). This evidence concerns the gene ROR2 and neoplasm.