Given that the mTOR pathway has been demonstrated to participate in regulating epithelial-mesenchymal transition, motilityand metastasis of CRC cells in previous studies [42, 43], our results showed the role of the miR-99b-5p–mTOR axis in CRC metastases in a more comprehensive way, both in cell lines and clinical samples. This evidence concerns the gene MTOR and colorectal carcinoma.