In the present study, we evaluated the co-expression of different SSTR (SSTR1, 2A, 3, 5) with CXCR4 in gastroenteropancreatic neuroendocrine neoplasms (G1-G3), comprising a total of 121 samples from 64 patients, the composition of which was comparable to previous studies, which reported the small intestine and the pancreas to represent the most frequent origins of NEN [18, 19]. The gene discussed is CXCR4; the disease is neuroendocrine neoplasm.