This identifies with high significance 51 genes of the M-Meis1 signature whose expression is down-regulated upon inhibition of the EGF-R (p = 2.13e−24) in differentiating normal cells, and 7 genes (p = 9.3e-6) upregulated in human lung cancer cells that overexpress a mutated form of Kras (Supplementary Table S4). Here, KRAS is linked to lung cancer.