Further possible candidate genes for PND include GCK, PDX1, GATA6, NEUROD1, NEUROG3, NKX2-2, IER3IP, PTF1A, HNF1B, RFX6, and MNX. Syndromes that incorporate PND include immunodysregulation polyendocrinopathy enteropathy X-linked syndrome (FOXP3), Wolcott-Rallison syndrome (EIF2AK3), and pancreatic agenesis (PDX1, PTF1A, GATA6, and GATA4) (1, 3). This evidence concerns the gene PDX1 and Wolcott-Rallison syndrome.