We queried the Oncomine database26 (http://oncomine.com) for publically available CRC microarray data and identified overexpression of SPINK1 in three independent CRC data sets, namely, Ki et al.,27 Gaspar et al.28 and the TCGA study.29 In Ki et al. data set while we observed significant SPINK1 upregulation (P=2.38e−7) in colon adenocarcinoma, interestingly the squamous-cell carcinomas showed downregulation (Figure 1a). Here, SPINK1 is linked to colon adenocarcinoma.