Analysis of other independent data sets generated using TCGA and Gaspar et al.28 studies further supported SPINK1 overexpression in colorectal adenocarcinoma relative to intestinal mucosa and normal colon (P=9.95e−4 and P=3.7e−4, respectively) (Figures 1b and c). Here, SPINK1 is linked to colorectal adenocarcinoma.