SPINK1 and neoplasm: SPINK1 knockdown in WiDr cells resulted in a significant reduction in tumor weight (Figure 6a; P=0.012), as well as decreased intravasation of shSPINK1 cells as compared with shSCRM cells (Figures 6b and c; P=0.02), suggesting that SPINK1 knockdown in WiDr cells impaired their ability to invade the CAM basement membrane and resulted in significantly decreased number of intravasated cells in the lower CAM.