PARP14 and hepatocellular carcinoma: Compared with control silencing, knockdown of PARP14 in multiple HCC cell lines resulted in decreased glucose consumption and lactate production (Fig. 3a,b; Supplementary Fig. 3a,b), accompanied by a reduced rate of extracellular acidification (ECAR) (Fig. 3c; Supplementary Fig. 3c), indicators of decreased aerobic glycolysis2, 4, 8.