An OR lower than 1.0 indicates that subjects who have the effect allele (minor allele ‘C,’ SQRDL I264T variant) in the rs1044032 SQRDL nsSNP might exhibit less susceptibility to osteoporosis than those with the non-effect allele (major allele ‘T,’ SQRDL I264 WT) in the nsSNP. This evidence concerns the gene SQOR and osteoporosis.