So far, a few nsSNPs have been reported to be associated with osteoporosis-related phenotypes: three variants (A1330V, Q89R and V667M) of the LRP5 gene were associated with BMD in many ethnic cohorts [12], an A152V variant of the BMP4 gene was associated with bone mass in Caucasian women [35], and an N19L variant of the CLEC2D gene was associated with BMD in Spanish women [36]. Here, BMP4 is linked to osteoporosis.