PTEN and familial pancreatic carcinoma: In addition, Sarker et al. reported that the treatment of pancreatic cancer cells with isoflavone mixture (G2535), formulated 3,3′-diindolylmethane (BR-DIM), or synthetic curcumin analogue (CDF) could downregulate the expression of miR-221 and consequently upregulate the expression of PTEN, p27Kip1, p57Kip2, and PUMA, leading to the inhibition of proliferation and migration of pancreatic cancer cells [42].