In a mouse model of medulloblastoma which overexpresses the activated form of intracellular Notch1 and decreased levels of p53, mice develop medulloblastoma tumors which closely mimic the Shh-subgroup of tumors, indicating that each pathway can crosstalk with the other, although Notch pathway activation is not necessary for the growth of Shh tumors [42,43,44]. The gene discussed is NOTCH1; the disease is medulloblastoma.