Strikingly, while these authors had previously shown that EndoG-N174A overexpression in MCF-7 cells did not induce a cell signaling response comparable to the one observed in response to the accumulation of truncated OTC in the mitochondrial matrix, in ERα-deficient breast cancer cells, they recently revealed that IMS stress also increases the expression of CHOP-10 and HSPD1 [84]. This evidence concerns the gene ENDOG and breast cancer.