COL6A3 and obesity due to melanocortin 4 receptor deficiency: This underlines the interconnection between inflammation and fibrosis within WAT, although their causal and temporal relationship in the development of obesity still needs to be defined.7 Indeed, overfeeding increased both inflammation and col6a3 expression in WAT9, 17 and proinflammatory factors enabled preadipocytes to synthetize ECM components.25