However, few research has however demonstrated that insulin sensitivity remained unaltered following HIIT [33] and moderate intensity exercise [33,35,46]In addition, there are multiple studies finding improved insulin sensitivity among sedentary non-diabetic subjects [24,41,51]An intriguing study demonstrated that 7 consecutive days of exercise at 60–75% of heart frequency reserve improved ISIcomposite with additional improvement of AUC in a T2D population [45]. Here, INS is linked to type 2 diabetes mellitus.