PARL and Insulin resistance: Specifically, down-regulated DEGs likely to regulate CL dysfunction include MSMO1 (methylsterol monooxygenase located in endoplasmic reticulum membrane, involved in cholesterol biosynthesis and induced by LH in GCs [58, 59]), VMA21 (vacuolar ATPase deficiency linked to autophagy and ER stress and metabolic syndrome [60–62]), and PARL (an integral mitochondrial protein that decreases mitochondrial abundance and integrity in response to insulin resistance [54–56]).