The DEGs included genes linked to premature ovarian failure (NTRK2)[85, 86], polycystic ovary syndrome (MEF2A)[87], signaling pathways regulating follicular development and angiogenesis, growth and survival of granulosa cells, and responses to gonadotropins (BAK1[88], BMP1[89], BMP4[89, 90], GADD45A[91], IFNGR1[92], IGFBP1[93], JAK2[94], MAPILC3A[95, 96], NOS3[97, 98], NOTCH2[99], PLK2[100, 101], PTEN[70], SFRP4[102], VCAN[103], YY1[104]). The gene discussed is IGFBP1; the disease is primary ovarian failure.