MiR-373 is an oncogene and can induce tumor initiation and progression in testicular germ-cell tumors by targeting tumor suppressor LATS2, and invasion and metastasis by targeting CD44, RECK, mTOR and SIRT1 in breast, colon cancer and fibrosarcoma, respectively [29–32]. Here, SIRT1 is linked to malignant colon neoplasm.