Since HIF-2α stabilization is observed in the vast majority of solid tumors (Franovic et al., 2009; Qing and Simon, 2009), we propose that in addition to ccRCC HIF-2α-mediated pexophagy might also lead to reduced peroxisome abundance in other cancer types. The gene discussed is EPAS1; the disease is nonpapillary renal cell carcinoma.