Huang et al. (2014) reported that HIF-1α, but not HIF-2α, represses MYC in human hepatoma cells and thereby decreases PGC-1β expression, leading to decreased expression of medium- and long-chain acyl-CoA dehydrogenases and subsequent inhibition of mitochondrial fatty acid β-oxidation. This evidence concerns the gene PPARGC1B and hepatocellular carcinoma.