HABP2 and cancer: The enzymatic activity of HABP2 is differentially regulated by hyaluronan (HA) with HMW-HA (the main form of HA in vivo) inhibiting HABP2 protease activity, while LMW-HA (produced in disease states including cancer via HMW-HA cleavage by hyaluronidase enzymes and ROS) binds to the PABD of HABP2 and stimulates activity (11).