CCK and neoplasm: Subsequent studies carried out in tumor specimens confirmed that CCK expression was high in the majority of Ewing sarcomas, whereas in other tumors, CCK-positive cases ranged from 50% in leiomyosarcomas to 0% in medulloblastomas, central primitive neuroectodermal tumors (PNET), neuroblastomas, and rhabdomyosarcomas (79).