LOX and Ewing sarcoma: Interestingly, the use of HDACs inhibitors (vorinostat/SAHA) or LSD1 inhibitors (HCI-2509) induced an increase in the levels of LOX mRNA in A673 Ewing sarcoma cells, which suggest that the anti-tumor effect of these drugs could be mediated, at least in part, by the upregulation of LOX (106).