Initial attempts in this direction have elucidated that the cancer cells in a hybrid E/M phenotype (identified by SNAIL+ E-cad+ in colon, and by EPCAM+ CD44+ CD47+ MET+ in breast cancer) can more efficiently act as seeds of metastasis (122, 123), hence establishing a clinical and prognostic relevance of the cells in the hybrid E/M phenotype. Here, CD44 is linked to cancer.