AKT1 and breast carcinoma: The activated ErbB receptors bind to Grb2 and Sos downstream mediators, resulting in the activation of intracellular signaling pathways such as Ras/Raf, MAPK, and the PI-3K/Akt pathways which are involved in cell growth, apoptosis, invasion, and migration of breast cancer cells [13, 14, 19, 20].