Accordingly, ceramide was shown to induce IL-1β secretion from macrophages in obese individuals and high-fat diet (HDF) fed animals [22], while at a mechanistic level, NEFAs activated the NOD-like receptor family and pyrin domain containing 3 (NLRP3) inflammasome in haematopoietic cells and promoted insulin resistance [23]. Here, NLRP3 is linked to Insulin resistance.