PDGFRA and gastrointestinal stromal tumor: Examples include well-established links between mutation in the Pdgfrα and gastrointestinal stromal tumours [31]; age dependent impairment of PDGFRα in the pancreas and heart may lead to impairment of the β-cell insulin productivity [32] and cardiac function [33], respectively, suggesting a crucial regulatory role that MSCs play in maintaining health of the normal tissue.