Keeping in view the pivotal role of Treg cells in the maintenance of immune balance and association of its master controller FOXP3 gene with autoimmune diseases, in our opinion, FOXP3 is a potential candidate gene which should be screened thoroughly for known and novel functional genetic variants and epigenetic modifications that regulate its expression; further to correlate the impact of these variations on Treg cell development, stability and function will be promising in understanding the genetic heterogeneity of vitiligo. This evidence concerns the gene FOXP3 and autoimmune disease.