In contrary, it was suggested that the reduced cell number and impaired function of natural Treg cells is associated with imbalance of CD4+/CD8+ ratio and was suggested to be involved in the T-cell mediated pathogenesis of vitiligo and its progression (Klarquist et al., 2010; Lili et al., 2012; Dwivedi et al., 2013). The gene discussed is CD4; the disease is vitiligo.