As it has been shown that up-regulation of miR-182, a known miRNA modulator of BRCA1, effectively renders cells BRCA1 deficient and therefore susceptible to such PARP inhibitors as 4-amino-1,8-naphthalimide or olaparib, it may be possible that forced expression of the miR-15/107 family, which are typically down-regulated in many cancers through various mechanisms, may be advantageous in chemo-sensitizing particular cancers (Moskwa et al., 2011). Here, BRCA1 is linked to cancer.