AIRE and autoimmune polyendocrine syndrome type 1: The importance of Aire in the induction of T-cell tolerance is illustrated by the fact that mutations in this gene are responsible for the development of the human autoimmune syndrome autoimmune polyendocrinopathy syndrome-1 (APS-1), which is also known as autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) (36, 37).