IGHE and infection: In repeated measures models, individuals with IgE but not IgG4 responses to rSj97 had a 77% lower intensity of reinfection at 12 months compared to individuals with IgG4 but not IgE responses, even after adjusting for potential confounders including directly observed water contact, village, age, sex, and baseline intensity of infection (p = 0.016) (28), see Figure 1B.