Whereas, some longitudinal studies have indicated a relationship between high cytokine levels, for example, interleukin-6 (IL-6) and C-reactive protein (CRP), and development of multiple forms of dementia, data from the MacArthur Study of Successful Aging indicated that there was only a limited association between inflammatory factors and baseline cognitive function and the rate of longitudinal cognitive decline after correcting for potential confounders (Weaver et al., 2002; Teunissen et al., 2003; Baune et al., 2008). This evidence concerns the gene CRP and dementia.