Hierarchical regression analyses (controlling for age, education, race, depression, pain, health comorbidity, and BMI) revealed that higher levels of CRP and sICAM are associated with higher global cognitive functioning in older men with sleep duration ≥6 h (β = −0.19, β = −0.18, p's < 0.05, respectively), but not in those with short sleep durations (p's > 0.05). This evidence concerns the gene CRP and depressive symptom measurement.