Knock-in mice in which Serine 105 was replaced with alanine in GATA4 failed to develop cardiac hypertrophy in response to pressure overload or adrenergic stimulation with phenylephrine, suggesting that phosphorylation of GATA4 in this position is crucial for GATA4 function (van Berlo et al., 2011). The gene discussed is GATA4; the disease is cardiac hypertrophy.