HTR1A and Cognitive impairment: Certainly, the situation is changing; e.g., Yoshimi et al. (2014) report that brexpiprazole, presents serotonin-dopamine activity, and 5-HT1A receptor partial agonism, attenuates phencyclidine-induced cognitive deficits; an effect blocked by the selective 5-HT1A receptor antagonist WAY-100,635 (which alone has no effect).