Examining protein and mRNA levels of these transporters in post-mortem prefrontal cortex from patients and matched non-AD controls, Chen et al. (2011) found that protein and mRNA levels of VGLUTs, EAAT1-3, VAChT, and SERT are reduced in AD, without changing DAT (Table 11). The gene discussed is SLC6A3; the disease is Alzheimer disease.