Likewise, Weber et al. (2015) report that conditional inactivation of the GLUA1-encoding Gria1 gene selectively in 5-HT neurons of adult mice (i.e., Gria1 5-HT-/- mice) exhibited a distinct anxiety phenotype but showed no alterations in locomotion, depression-like behavior, or learning and memory. The gene discussed is GRIA1; the disease is major depressive disorder.