PPARG and early-onset autosomal dominant Alzheimer disease: In addition to NFκB, other transcription factors are activated by inflammatory conditions, such as peroxisome proliferator-activated receptor gamma (PPARγ) and signal transducer and activator of transcription (STAT-1) and have also been implicated in Alzheimer’s disease (AD; Sastre et al., 2006; Cho et al., 2007).