A relationship between iron and amyloid plaques has been established in AD tissue (Smith et al., 1997; Collingwood et al., 2008; Meadowcroft et al., 2009; Ayton et al., 2013) and, to a lesser extent, in the APP/PS1 model (Jack et al., 2004; El Tannir El Tayara et al., 2006; Meadowcroft et al., 2009; Chamberlain et al., 2011; Wengenack et al., 2011; Wadghiri et al., 2012; Bourassa et al., 2013). The gene discussed is PSEN1; the disease is Alzheimer disease.