Studies have shown that STIM1 affects the cell cycle in various cell lines17, 21, and STIM1 knockdown in cervical cancer cells inhibits cell growth by arresting the cells at the S and G2/M phases with increased protein expression level of p21 and decreased expression of Cdc25C and might inhibit Cdk1 activation, leading to cell cycle arrest12. This evidence concerns the gene CDK1 and cervical cancer.