In addition, using STIM1 and STIM2 conditional knock-out mice, the function of SOCE in CD8+ T cells has been shown to play a vital role in regulating the degranulation of cytotoxic T lymphocytes (CTLs) as well as their expression of the Fas ligand and the production of IFN-γ and TNF-α; thus, SOCE is required to prevent the development of melanoma and colon carcinoma cells50 . This evidence concerns the gene TNF and melanoma.