In addition, the transcripts of VEGFA and MMP9 in U937 were also significantly reduced after treatment with the CM from DU145 or PC3 cells overexpressing STIM1-YFP and /or ORAI1, suggesting that the TME of prostate cancer cells with enhanced SOCE activity may be unfavorable to tumor growth and metastasis. The gene discussed is ORAI1; the disease is Familial prostate cancer.