Interestingly, although STIM1 has been reported to promote the expression of VEGFA in tumor cells, the treatment of macrophages with the culture media from DU145-STIM1-YFP and PC3-STIM1-YFP cells reduced their mRNA expression of VEGFA and MMP9; combined with the promotion of an unfavorable TME, these factors may therefore compromise the effect of STIM1 on angiogenesis and the metastasis of prostate cancer cells. The gene discussed is MMP9; the disease is prostate cancer.