STIM1 and neoplasm: Interestingly, although STIM1 has been reported to promote the expression of VEGFA in tumor cells, the treatment of macrophages with the culture media from DU145-STIM1-YFP and PC3-STIM1-YFP cells reduced their mRNA expression of VEGFA and MMP9; combined with the promotion of an unfavorable TME, these factors may therefore compromise the effect of STIM1 on angiogenesis and the metastasis of prostate cancer cells.