ORAI1 and neoplasm: Significantly reduced immunofluorescence staining of BrdU positive cells (Fig. 7BC), and increased Immunohistochemical stainings of DcR2 were found in DU145-STIM1-YFP, DU145-ORAI1 and DU145-STIM1-YFP-ORAI1 tumor xenografts (Fig. 7D); these findings support the idea that STIM1 and ORAI1 inhibit the tumor cell cycle and accelerate senescence.