Studies have shown that STIM1 affects the cell cycle in various cell lines17, 21, and STIM1 knockdown in cervical cancer cells inhibits cell growth by arresting the cells at the S and G2/M phases with increased protein expression level of p21 and decreased expression of Cdc25C and might inhibit Cdk1 activation, leading to cell cycle arrest12. The gene discussed is CDC25C; the disease is cervical carcinoma.