The second ranked pathway was the Phosphatidylinositol Signaling System (CALML3, PIP5K3, PLCE1 and SYNJ1) and the third was the Colorectal Cancer-related pathway (including ACVR1C, AKT2, FZD6, MSH2, and TGFBR1). The gene discussed is FZD6; the disease is colorectal cancer.