Therefore, in order to identify and describe the possible roles of Th22 and Th17 subsets in the pathogenesis of MM, we investigated the proportions of pure Th17 (CD4+ IFN-γ−IL-17A+IL-22− T cells), pure Th22 (CD4+IFN-γ−IL-22+IL-17A− T cells) as well as Th1 cells (CD4+IFN-γ+ T cells) in the peripheral blood and bone marrow by flow cytometry, concentrations of plasma IL-17A, IL-22 and IFN-γ by enzyme-linked immunosorbent assay (ELISA) along with the mRNA expression levels of RORC, AHR in Chinese patients with MM. This evidence concerns the gene IFNG and Miyoshi myopathy.