Since parts of the TGFβ signaling pathway are shown to be mutated in cancer cells (see for the details in [66]), this allows cancer cells to escape TGFβ-induced cell cycle block, differentiation or apoptosis, while the surrounding stromal, immune, endothelial and smooth muscle cells still read the TGFβ signaling as a potent suppressor of proliferation and trigger of differentiation causing immunosuppression and angiogenesis in the cancer cell microenvironment. Here, TGFB1 is linked to cancer.