Beyond the VEGF-A and KDR, several genes, such as VEGFR3 or Flt4 [10], Platelet-derived growth factor (PDGF) and PDGF receptor-α (PDGFRα) [11], Hypoxia-inducible factor-1α (HIF-1α) [12], and Excision repair cross-complementation group 1 (ERCC1) [13], have been also associated with tumour angiogenesis and malignant progression. The gene discussed is FLT4; the disease is neoplasm.