VEGFA and anemia: Our present study found that curcumin significantly improved severe anemia and extramedullary hematopoiesis in livers and spleens of tumor-bearing mice induced by tumor-derived VEGF and prolonged survival time of tumor-bearing mice, which provides the robust evidences that curcumin has the ability to improve quality of life of tumor-bearing mice through inhibiting VEGF mediated angiogenesis.