Interestingly, low dose of curcumin used in this study showed no significant effect on tumor growth inhibition, but significantly improved anemia and extramedullary hematopoiesis in livers and spleens of tumor-bearing mice induced by VEGF, which indicates that curcumin does not always inhibit tumor size and growth, but still can benefit tumor-bearing mice through inducing systemic alterations of the vasculature that modulate the function of various tissues and organs in tumor-bearing mice. Here, VEGFA is linked to anemia.