VEGFA and neoplasm: In order to further validate the mechanism of curcumin on liver hematopoiesis, immunohistochemical analysis was conducted for liver sections and highly dilated sinusoidal hepatic vasculatures were observed in livers of VEGF tumor-bearing mice but not in livers of normal mice, while curcumin obviously reduced vessel dilation and normalized vascular architecture of livers in VEGF tumor-bearing mice (Figure 5A).