In our study, we also found that livers and spleens of T241-VEGF tumor-bearing mice were significantly different with that of normal mice, the coefficients of livers and spleens of tumor-bearing mice were significantly increased, while liver coefficients and spleen coefficients of curcumin treated groups were significantly decreased, especially for mice treated with high dose of curcumin (Figure 3E, 3F), which suggests that curcumin inhibited hematopoiesis in livers and spleens of tumor-bearing mice induced by tumor-derived VEGF with a dose dependent manner. Here, VEGFA is linked to neoplasm.