Furthermore, immunohistochemical analyses of 163 paired CRC samples showed that the immunoreactivity of DHRS9 protein was observed in the cytoplasm, and 91.4 % (149/163) of the normal colorectal mucosa tissues tested were classified as DHRS9-positive, whereas only 57.7 % (94/163) of the cancerous samples were classified as DHRS9-positive. This evidence concerns the gene DHRS9 and colorectal carcinoma.