Carbamazepine-induced SJS/TEN has shown a strong (odds ratio >1000) association with HLA-B*15:02 in the Han Chinese population.35-37 This association has also been replicated in several other Asian populations, including Thai,38,39 Malay,40 and Indian subjects41 but not in white9,42,43 and Japanese subjects.44,45 Apart from being ethnicity specific, the association with HLA-B*15:02 is phenotype specific in that it is only valid for SJS/TEN but has not been shown to be important for maculopapular exanthema and hypersensitivity syndrome.36 This evidence concerns the gene HLA-B and toxic epidermal necrolysis.